Tribbles 3 deficiency promotes atherosclerotic fibrous cap thickening and macrophage-mediated extracellular matrix remodelling
Tribbles 3 (TRIB3) modulates lipid and glucose metabolism, macrophage lipid uptake, with a gain-of-function variant associated with increased cardiovascular risk.Here we set out to examine the role of this pseudokinase in atherosclerotic plaque development.Human endarterectomy atherosclerotic tissue specimens BCAA SPIKED XDM MANGO analysed by immun